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Medical Science Optional daily answer writing practice for CSE 2024 – Feb 21

Topic: Laryngeal tumour, oral and esophageal tumours

Question: Write shortly on a) venous ulcer b)pleomorphic adenoma of parotid glands.

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Venous ulcers are chronic wounds that result from impaired venous circulation, typically occurring in the lower extremities. They are often associated with venous insufficiency, where the normal flow of blood back to the heart is compromised, leading to increased pressure in the veins.

Etiology:

  1. Venous Insufficiency:
    • Chronic venous hypertension damages the valves in the veins, causing blood to pool in the lower extremities.
    • Increased pressure results in fluid leakage and inflammation, contributing to ulcer formation.
  2. Deep Vein Thrombosis (DVT):
    • Clots in the deep veins can obstruct blood flow, leading to venous congestion and ulceration.
  3. Varicose Veins:
    • Dilated and tortuous veins can contribute to venous insufficiency, exacerbating the development of ulcers.

Clinical Presentation:

  1. Location:
    • Typically found on the lower legs, near the ankles.
    • Irregularly shaped with shallow, often painful ulcerations.
  2. Characteristics:
    • Surrounding skin may be edematous, hyperpigmented, and exhibit signs of chronic inflammation.
    • Presence of venous stasis dermatitis, lipodermatosclerosis, and hemosiderin staining.
  3. Pain and Discomfort:
    • Pain is often described as aching or throbbing, especially when the legs are dependent.

Diagnosis:

  1. Clinical Evaluation:
    • Detailed medical history and physical examination.
    • Assessment of venous insufficiency through Doppler ultrasound.
  2. Differential Diagnosis:
    • Arterial ulcers, diabetic ulcers, or other dermatological conditions.

Management:

  1. Compression Therapy:
    • Compression bandages or stockings to reduce edema and promote venous return.
  2. Wound Care:
    • Regular cleaning and debridement of the ulcer.
    • Dressings to maintain a moist healing environment.
  3. Elevation:
    • Encouraging leg elevation to reduce edema.
  4. Pharmacotherapy:
    • Topical or systemic antibiotics if infection is present.
  5. Surgical Intervention:
    • Occasionally, surgical procedures like vein ligation or venous bypass may be considered.

Prevention:

  1. Compression Stockings:
    • To prevent recurrence and manage symptoms.
  2. Regular Exercise:
    • Enhances calf muscle pump function.
  3. Weight Management:
    • Maintaining a healthy weight to reduce venous pressure.

Conclusion: Venous ulcers pose a significant challenge in patient care, requiring a comprehensive approach that addresses the underlying venous insufficiency, wound management, and preventive strategies to minimize recurrence.

Pleomorphic adenoma is the most common benign tumor of the salivary glands, frequently arising in the parotid glands. It is characterized by a diverse histological appearance and typically presents as a slow-growing, painless mass.

Histopathology:

  1. Mixed Cellularity:
    • Comprises both epithelial and myoepithelial cells.
    • Variable patterns, including ductal structures and myxoid stroma.
  2. Chondromyxoid Matrix:
    • Presence of chondroid and myxoid components.
  3. Capsule Formation:
    • Typically encapsulated, facilitating surgical removal.

Clinical Presentation:

  1. Location:
    • Predominantly found in the superficial lobe of the parotid gland.
  2. Palpable Mass:
    • Typically painless, slow-growing mass that may become noticeable over time.
  3. Facial Nerve Involvement:
    • Rarely involves the facial nerve.
    • Tumors are usually mobile and discrete.

Imaging:

  1. Ultrasound:
    • Differentiates solid from cystic lesions.
    • Can assess for features suggestive of malignancy.
  2. MRI or CT Scan:
    • Provides detailed information on the extent and characteristics of the tumor.
    • Useful for surgical planning.

Treatment:

  1. Surgical Excision:
    • Complete surgical removal is the primary treatment.
    • Preservation of facial nerve function is a priority.
  2. Fine Needle Aspiration (FNA):
    • Preoperative FNA can aid in diagnosis and guide surgical planning.
  3. Recurrence:
    • Despite being benign, there is a risk of recurrence if not completely excised.

Complications:

  1. Facial Nerve Injury:
    • Careful dissection is required to avoid damage to the facial nerve.
  2. Recurrence:
    • Incomplete excision may lead to recurrence.

Prognosis:

  1. Benign Nature:
    • Pleomorphic adenomas are typically benign, and malignant transformation is rare.

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