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Medical Science Optional daily answer writing practice for CSE 2023 – Dec 7

Topic:Immunization, Baby friendly hospital, congenital cyanotic heart disease

Question: Classify and discuss the management of adverse events following vaccination.

Click here for Reference Material-This material is informational alone and is not specifically prepared as an answer for any question. Readers may do their own research before finalising diagnoses according to the characteristics unique to each question. Readers should not proceed without cross-referencing with relevant textbooks as well as standard guidelines available.

Adverse event following immunization (AEFI) is defined as any untoward medical
occurrence which follows immunization and which does not necessarily have a causal
relationship with the usage of the vaccine.

Coincidental Adverse Events:

  • Not due to vaccine but occur by chance post-vaccination.
  • No specific management required other than monitoring and reassurance.

Local Reactions:

  • Pain, redness, swelling at injection site within 2 days.
  • Management involves reassurance, encouraging movement of injected limb, and analgesic like paracetamol or ibuprofen for older children/adults if needed. Application of a cold compress may help relieve discomfort.

Systemic Events:

  • Fever, irritability, loss of appetite typically occurring within 3 days and resolving within 2-3 days.
  • Treatment involves efforts to bring down fever with antipyretics like paracetamol or ibuprofen, and ensuring proper fluid intake. Medical attention needed if fever is high (>39°C) or persists beyond 3 days.

Allergic Reactions:

  • Mild symptoms like rash, itching can be managed with oral antihistamines.
  • Anaphylaxis is a medical emergency requiring immediate treatment with intramuscular epinephrine injection into lateral thigh, supplemental oxygen, IV fluids and close monitoring. Further doses of epinephrine or other resuscitative measures may be needed. Patient should be observed for biphasic reactions for 4-6 hours even after initial symptoms resolve.

Vaccine-Related Adverse Events:

  • Management depends on specific event but may include intensive supportive care, corticosteroids, respirators or other organ support measures in an ICU setup.

Proper documentation, counseling and timely referral/hospitalization are key aspects of management along with surveillance to monitor long term outcomes.

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