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Medical Science Optional daily answer writing practice for CSE 2024 – Feb 19

Topic: Diagnosis and management of anemia. Preeclampsia and Toxemia of pregnancy

Question: Write Short Essays:
1. Management of Abnormal Uterine Bleeding (AUB) in 20 years old girl
2. Cervical Intraepithelial Neoplasia (CIN) management.

Click here for Reference Material-This material is informational alone and is not specifically prepared as an answer for any question. Readers may do their own research before finalising diagnoses according to the characteristics unique to each question. Readers should not proceed without cross-referencing with relevant textbooks as well as standard guidelines available.
  • Abnormal Uterine Bleeding (AUB) refers to irregular menstrual bleeding that deviates from the normal pattern.
  • In a 20-year-old girl, AUB can have various causes, including hormonal imbalances, structural abnormalities, or systemic conditions.

Diagnosis:

  1. Medical History:
    • Collect information on the girl’s menstrual history, including cycle regularity, duration, and flow intensity.
    • Inquire about associated symptoms such as pain, clots, or intermenstrual bleeding.
  2. Physical Examination:
    • Perform a pelvic examination to assess for structural abnormalities or signs of infection.
    • Check for signs of systemic conditions impacting menstrual health.
  3. Laboratory Tests:
    • Hormonal assays to evaluate thyroid function, prolactin levels, and ovarian function.
    • Coagulation studies to rule out bleeding disorders.
    • Pap smear to exclude cervical pathology.
  4. Imaging Studies:
    • Ultrasound to assess the uterus and ovaries for structural abnormalities.
    • Hysteroscopy may be indicated for further evaluation of the uterine cavity.

Management:

  1. Hormonal Therapy:
    • Oral contraceptives to regulate menstrual cycles.
    • Progestin therapy for those with anovulatory cycles.
  2. Non-Hormonal Options:
    • Nonsteroidal anti-inflammatory drugs (NSAIDs) for pain and to reduce bleeding.
    • Tranexamic acid to control heavy bleeding.
  3. Surgical Interventions:
    • Dilation and curettage (D&C) if there’s suspicion of retained products of conception.
    • Endometrial ablation for persistent bleeding refractory to medical management.
  4. Treatment of Underlying Conditions:
    • Addressing thyroid disorders, bleeding disorders, or other systemic issues.
  5. Lifestyle Modifications:
    • Nutritional counseling, exercise, and stress management to promote overall health.
  6. Follow-up:
    • Regular monitoring to assess the response to treatment.
    • Adjustments in management based on the individual’s progress.

  • Cervical Intraepithelial Neoplasia (CIN) represents pre-cancerous changes in the cervical epithelium, often caused by persistent human papillomavirus (HPV) infection.
  • Early detection and management are crucial to prevent the progression to cervical cancer.

Diagnosis:

  1. Pap Smear:
    • Routine screening to detect abnormal cervical cells.
    • Categorization based on the Bethesda system.
  2. HPV Testing:
    • Identifying the presence of high-risk HPV types, which may indicate a higher risk of developing CIN.
  3. Colposcopy:
    • Visual examination of the cervix using a colposcope for detailed assessment.
  4. Biopsy:
    • Confirmatory biopsy to determine the extent and severity of CIN.

Management:

  1. Watchful Waiting:
    • For low-grade CIN, especially in young women, as it can regress spontaneously.
  2. LLETZ (Large Loop Excision of the Transformation Zone):
    • Excisional procedure to remove the affected cervical tissue.
    • Also serves as a diagnostic and therapeutic intervention.
  3. Cryotherapy:
    • Freezing of abnormal cervical cells to destroy them.
  4. Laser Therapy:
    • Precise removal of abnormal cells using laser technology.
  5. Medical Management:
    • Topical application of agents like imiquimod or topical chemotherapy.
  6. Regular Follow-up:
    • Periodic screenings and colposcopies to monitor for recurrence or progression.

Vaccination:

  • Encouraging HPV vaccination for both males and females to prevent future infections.

Psychosocial Support:

  • Providing emotional support and counseling due to the psychological impact of a CIN diagnosis.

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